Senior Laboratory Research Scientist
About the role…
The Gutierrez lab is in the research group “Host-pathogen interactions in tuberculosis” and has a long-standing interest in developing novel human induced pluripotent stem cell (iPSC)-based in vitro models of complex disease to study infection and treatment (Pellegrino et al.,2021; Aylan et al., 2023; Bussi et al., 2023). The SLRS position has been created to ensure the successful implementation of projects that aim to develop bioengineered stem cells based cellular systems to better understand lung infection and treatment. Specifically, we are engineering physiologically inspired human lung models combining human (iPSC) technologies with microfluidic devices.
This role is critical to generate tools and perform cell-based experiments, requiring substantial experience in human induced pluripotent stem cell (iPSC) culture, differentiation and reprogramming. Experience in CRISPR/Cas9 genome editing is desirable. You will be part of a diverse and collegial team focused on advancing human iPSC-derived technologies to study infection and treatment. You will provide deep technical knowledge and hands-on expertise in the culture, characterisation and differentiation of human iPSCs into lung cells.
What you will be doing…
As an SLRS at the Crick, you will:
- iPSC culture and maintenance
- iPSC differentiation and differentiated cell production
- iPSC characterisation
- Somatic cell reprogramming into iPSC
- iPSC gene editing