BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Life Science Index - ECPv6.18.2//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-ORIGINAL-URL:https://lsindex.co.uk X-WR-CALDESC:Events for Life Science Index REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/London BEGIN:DAYLIGHT TZOFFSETFROM:+0000 TZOFFSETTO:+0100 TZNAME:BST DTSTART:20250330T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0100 TZOFFSETTO:+0000 TZNAME:GMT DTSTART:20251026T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0000 TZOFFSETTO:+0100 TZNAME:BST DTSTART:20260329T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0100 TZOFFSETTO:+0000 TZNAME:GMT DTSTART:20261025T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0000 TZOFFSETTO:+0100 TZNAME:BST DTSTART:20270328T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0100 TZOFFSETTO:+0000 TZNAME:GMT DTSTART:20271031T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/London:20260112T000000 DTEND;TZID=Europe/London:20260115T235959 DTSTAMP:20251201T121239Z CREATED:20250227T150238Z LAST-MODIFIED:20251201T121239Z UID:2428-1768176000-1768521599@lsindex.co.uk SUMMARY:Pain and distress in laboratory animals DESCRIPTION:Understanding\, preventing and alleviating pain and distress is a key part of the responsibilities of many animal care staff. This may involve directly evaluating the welfare state of animals and implementing refinements to their care or participating in the ethical review process and contributing to the harm: benefit analysis of research projects. \nThis unit provides an overview of pain and distress in laboratory animals\, gives an introduction to pain and nociception\, and current concepts of animal welfare. It provides detailed information on evaluating and managing pain in rodents\, and an overview of pain in larger species and in non-mammalian species. The evaluation of severity of research procedures is discussed\, together with the issues surrounding cumulative severity and retrospective assessment of procedures. \nOnline only – Zoom 12-15th Jan 2026. Pre-course material will be available two weeks before the course starts.  \nWe highly recommend completion of the level 4 unit Physiology of pain and distress in laboratory animals\, and the level 5 unit Recognition of pain\, suffering and distress\, before attending this unit. \nCourse Details\nDiploma Credits: 30 \nIAT CPD Credits: 60 \nTutors: Paul Flecknell / Matt Leach \nYou will cover\n\nCurrent concepts:  pain\, distress and animal welfare\nNormal behavior\nMethods for assessing and recording the welfare of animals\nHumane end points\nSeverity classifications\nTeam approach\nMinimising pain and distress\n\nKey Skills you will develop\n\nAn understanding of current concepts of pain and distress and animal welfare\nAbility to recognise normal or desirable behaviour and appearance of animals\, and abnormal behaviour and signs of discomfort\, pain\, suffering\, or distress\nAbility to describe what a humane end point is and discuss their use\nAbility to describe the severity classifications\nKnowledge and understanding of the use of refinement to minimize welfare concerns\nKnowledge and understanding of effective welfare assessment strategies\n\n  \n*Further IAT fees may apply URL:https://lsindex.co.uk/event/pain-and-distress-in-laboratory-animals/ LOCATION:online CATEGORIES:Training and CPD Events ATTACH;FMTTYPE=image/jpeg:https://lsindex.co.uk/wp-content/uploads/2025/02/pain-and-distress-course.jpg ORGANIZER;CN="CLAST":MAILTO:enquiries@clast.org.uk END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/London:20260114T093000 DTEND;TZID=Europe/London:20260114T163000 DTSTAMP:20251201T135418Z CREATED:20250904T130411Z LAST-MODIFIED:20251201T135418Z UID:3350-1768383000-1768408200@lsindex.co.uk SUMMARY:Practical Laboratory Skills DESCRIPTION:Having the knowledge and confidence to work safely in the laboratory is an essential skill for all staff working in laboratories. This course will cover basic theoretical and practical laboratory skills including preparing COSHH risk assessments\, good laboratory practice\, use of fume hoods/biosafety cabinets\, centrifuges and other laboratory equipment\, pipetting skills\, using balances and preparing reagents and solutions.\n\nA sustainability module is also included to highlight ways to reduce the environmental impact of laboratory work. Participants will explore practical ways to improve sustainability in the laboratory by reducing energy consumption and minimising the use of plastics and water and promoting more sustainable supply chain practices.\n\nWho is this for?\n\n Research Staff\n Technical Staff and students new to the laboratory environment\n Experienced personnel looking to refresh their skills\n\nAfter the course you will be able to:\n\n Prepare and understand the purpose of Control of Substances Hazardous to Health (COSHH) risk assessment (RA) forms\n Understand the importance of good laboratory practice\, including choosing appropriate personal protective equipment (PPE) and maintaining accurate laboratory records\n Correctly use fume hoods\, biosafety cabinets\, centrifuges and other general laboratory equipment\n Choose the correct pipette for your task and perform common techniques\n Set up and use balances correctly\n Prepare reagents and solutions\n Adjust the pH of solutions\n Incorporate sustainability considerations into laboratory work to support efficient and environmentally responsible research\n\n\n\n\nThis training is approved by the Royal Society of Biology. Training course approval is an independent review process that recognises relevant\, high quality training. Upon completion of this course\, attendees can claim 21 CPD points. URL:https://lsindex.co.uk/event/practical-laboratory-skills-2/ LOCATION:Advance training centre\, MRC Harwell\, Harwell Campus\, OX11 0RD CATEGORIES:Training and CPD Events ATTACH;FMTTYPE=image/jpeg:https://lsindex.co.uk/wp-content/uploads/2025/09/Hero-Template_v08-Lab-Skills_Practical-Laboratory-Skills-2.jpg ORGANIZER;CN="Mary Lyon Centre at MRC Harwell":MAILTO:training@har.mrc.ac.uk END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/London:20260127T093000 DTEND;TZID=Europe/London:20260127T170000 DTSTAMP:20251201T142520Z CREATED:20251201T142519Z LAST-MODIFIED:20251201T142520Z UID:3832-1769506200-1769533200@lsindex.co.uk SUMMARY:Genome Engineering and Validation by Long Read Sequencing DESCRIPTION:This interactive training session explores the use of long read sequencing (LRS) technologies for validating engineered alleles in both cellular and embryonic genome engineering contexts. Participants will learn the principles of genome editing design\, how LRS compares to traditional validation methods\, and how to select the appropriate sequencing modality for different allele types and experimental materials.\n\nWho is this for?\n\nThis workshop is designed for Early-career researchers and Experienced technicians\n\n seeking foundational knowledge in genome editing and sequencing technologies.\n aiming to refine protocols\, troubleshoot workflows\, and deepen data analysis skills.\n\nThis course covers topics including:\n\n A primer on genome editing strategies and allele design\n Protocols for sequencing and data generation\n Software tools for data analysis\n Hands-on exercises with real datasets\n Case studies from in-house and outsourced sequencing projects\n\nLearning Outcomes:\n\n Understand genome editing principles and allele design strategies\n Learn the rationale for using LRS in validation workflows\n Gain confidence in interpreting sequencing data and alignment files\n Update and optimize genome editing and sequencing protocols\n Compare LRS platforms and outsourcing options\n Deepen skills in troubleshooting and data analysis using .bam files\n\nWorkshop Agenda:\n\n1. Genome Editing Principles & Allele Design\n\n Overview of genome editing technologies (e.g.\, CRISPR/Cas9\, base editing)\n Strategies for designing engineered alleles\n Design implications for validation\n Considerations for validation in cells and animals\n\n2. Targeted Sequencing Modalities\n\n Why use LRS instead of Sanger?\n Overview of LRS platforms and their relevance to allele validation\n Choosing the right approach for your allele and material\n\n3. Experimental Workflows\n\n Sample preparation and library construction\n Platform-specific considerations (e.g.\, ONT\, PacBio)\n Adaptations for sample types (cell culture\, founder animals\, subsequent generation)\n\n4. Step-by-Step Protocols\n\n Practical guidance for generating high-quality data\n\n5. Data Analysis & Software Tools\n\n Principles of LRS data interpretation\n Overview of analysis software\n Guided exercises with real datasets\n\n6. Deep Dive into Alignment Files (.bam)\n\n How to read and interpret .bam files\n Examples from in-house and outsourced sequencing\n Platform-specific nuances and troubleshooting URL:https://lsindex.co.uk/event/genome-engineering-and-validation-by-long-read-sequencing/ LOCATION:Advance training centre\, MRC Harwell\, Harwell Campus\, OX11 0RD CATEGORIES:Training and CPD Events ATTACH;FMTTYPE=image/jpeg:https://lsindex.co.uk/wp-content/uploads/2025/12/Hero-Template_v08-Transgenics_Genome-Engineering.jpg ORGANIZER;CN="Mary Lyon Centre at MRC Harwell":MAILTO:training@har.mrc.ac.uk END:VEVENT END:VCALENDAR